Drug Information

Drug General Information
Drug ID
D0FD0H
Former ID
DAP000200
Drug Name
Aminocaproic Acid
Synonyms
ACS; Acepramin; Acepramine; Afibrin; Amicar; Amikar; Aminocaproate; Aminocaproic; Aminokapron; Atsemin; Caplamin; Capracid; Capralense; Capramol; Capranol; Caproamin; Caprocid; Caprolisin; EACA; EACS; Epsamon; Epsicaprom; Epsicapron; Epsikapron; Epsilcapramin; Epsilcapramine; Hemocaprol; Hemopar;Hepin; Ipsilon; Respramin; Acide aminocaproique; Acide aminocaproique [French]; Acide aminocaproque; Acido aminocaproico; Acidum aminocaproicum; Acidum aminocaproicum [Latin]; Aminocaproic Acid In Plastic Container; Aminocaproic Acids; Aminohexanoic acid; Eaca kabi; Epsilon Aminocaproic Acid; Epsilon S; A 7824; CL 10304; CY 116; CY116; JD 177; Acide aminocaproique [INN-French]; Acido aminocaproico [DCIT,Spanish]; Acido aminocaproico [INN-Spanish]; Acidum aminocaproicum [INN-Latin]; Amicar (TN); Aminocaproic acid (USP); CL-10304; CY-116; EPSILON-AMINOCAPROIC ACID; Epsilon-Ahx; Epsilon-Aminocaproic acid; Epsilon-Aminocapronsaeure; Epsilon-Aminohexanoic acid; Epsilon-Leucine; Epsilon-Norleucine; Epsilon-aminocaproate; Epsilon-aminocapronzuur; Fullevir (TN); Kyselina omega-aminokapronova; Kyselina omega-aminokapronova [Czech]; Omega-Aminocaproic acid; Omega-Aminohexanoic acid; S04-0132; Acid, 6-Aminocaproic; Acid, 6-Aminohexanoic; Acid, epsilon-Aminocaproic; Aminocaproic acid (USP/INN); Aminocaproic acid [USAN:BAN:INN]; Aminocaproic acid [USAN:INN:BAN]; Epsilon-Aminocaproic acid (JAN); HEXANOIC ACID,6-AMINO; Epsilon-Amino-n-caproic acid; Epsilon-Amino-n-hexanoic acid; Amicar, A-amino caproic acid, A-Ahx, 6-aminohexanoic acid, Aminocaproic acid; 6 Aminocaproic Acid; 6 Aminohexanoic Acid; 6-Amino-n-hexanoic acid; 6-Aminocaproic acid; 6-amino-hexanoic acid; 6-amino-n-caproate; 6-amino-n-caproic acid; 6-aminohexanoate; 6-aminohexanoic acid
Drug Type
Small molecular drug
Indication Excessive postoperative bleeding [ICD9: 459; ICD10:R58] Approved [538232], [541697]
Therapeutic Class
Antifibrinolytic Agents
Company
Intelfarm Co.
Structure
Download
2D MOL

3D MOL
Formula
C6H13NO2
InChI
InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
InChIKey
SLXKOJJOQWFEFD-UHFFFAOYSA-N
CAS Number
CAS 60-32-2
PubChem Compound ID
564
PubChem Substance ID
5420, 87073, 127775, 471451, 588079, 608071, 3131896, 4656524, 7847228, 7885665, 7885778, 7978686, 8143494, 8149196, 8150692, 10529215, 11110778, 11110779, 11133308, 11335726, 11360965, 11362812, 11365374, 11367936, 11373725, 11376098, 11461937, 11466988, 11468108, 11483938, 11486845, 11487947, 11491958, 11493852, 15119949, 17404645, 24278238, 24438930, 24701164, 24890662, 26522162, 26611600, 26679239, 26703793, 26717434, 26718589, 26747439, 26747440, 46391648, 46394356
ChEBI ID
ChEBI:32396
SuperDrug ATC ID
B02AA01
SuperDrug CAS ID
cas=000060322
Target and Pathway
Target(s) Plasminogen Target Info Inhibitor [535448], [535741]
KEGG Pathway Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Staphylococcus aureus infection
Influenza A
PANTHER Pathway Blood coagulation
Plasminogen activating cascade
Pathway Interaction Database Angiopoietin receptor Tie2-mediated signaling
p75(NTR)-mediated signaling
amb2 Integrin signaling
Syndecan-4-mediated signaling events
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PathWhiz Pathway Coagulation
Reactome Platelet degranulation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Dissolution of Fibrin Clot
WikiPathways Complement and Coagulation Cascades
Human Complement System
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activation of Matrix Metalloproteinases
Blood Clotting Cascade
Dissolution of Fibrin Clot
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 538232FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 071192.
Ref 541697(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6574).
Ref 535448The blockage of the high-affinity lysine binding sites of plasminogen by EACA significantly inhibits prourokinase-induced plasminogen activation. Biochim Biophys Acta. 2002 Apr 29;1596(2):182-92.
Ref 535741Analysis of plasmin binding and urokinase activation of plasminogen bound to the Heymann nephritis autoantigen, gp330. Arch Biochem Biophys. 1992 Dec;299(2):255-60.

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