| Drug General Information |
| Drug ID |
D0F8YO
|
| Former ID |
DNC005401
|
| Drug Name |
2-[3-(1-Hydroxy-propyl)-phenyl]-propionic acid
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C12H16O3
|
| Canonical SMILES |
CCC(C1=CC=CC(=C1)C(C)C(=O)O)O
|
| InChI |
1S/C12H16O3/c1-3-11(13)10-6-4-5-9(7-10)8(2)12(14)15/h4-8,11,13H,3H2,1-2H3,(H,14,15)
|
| InChIKey |
HTWFANVWNDWYRH-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
High affinity interleukin-8 receptor A |
Target Info |
Inhibitor |
[1]
|
|---|
| High affinity interleukin-8 receptor B |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Cytokine-cytokine receptor interaction
|
|
Chemokine signaling pathway
|
|
Endocytosis
|
|
Epithelial cell signaling in Helicobacter pylori infectionhsa04060:Cytokine-cytokine receptor interaction
|
|
Epithelial cell signaling in Helicobacter pylori infection
|
|
NetPath Pathway
|
IL2 Signaling PathwayNetPath_9:TNFalpha Signaling Pathway
|
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PANTHER Pathway
|
Inflammation mediated by chemokine and cytokine signaling pathway
|
|
Interleukin signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway
|
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Interleukin signaling pathway
|
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Pathway Interaction Database
|
IL8- and CXCR1-mediated signaling eventsil8cxcr2_pathway:IL8- and CXCR2-mediated signaling events
|
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Reactome
|
Chemokine receptors bind chemokines
|
|
G alpha (i) signalling eventsR-HSA-380108:Chemokine receptors bind chemokines
|
|
G alpha (i) signalling events
|
|
WikiPathways
|
GPCRs, Class A Rhodopsin-like
|
|
Differentiation Pathway
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|
Peptide GPCRs
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|
GPCR ligand binding
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GPCR downstream signaling
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|
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
|
|
GPCRs, Other
|
| References |
| REF 1 | J Med Chem. 2005 Jun 30;48(13):4312-31.2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. |
|---|
