Drug Information
Drug General Information | |||||
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Drug ID |
D0F8CM
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Former ID |
DAP001025
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Drug Name |
Pentosan Polysulfate
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Synonyms |
Elmiron; Pentosan sulfuric polyester; Polypentose sulfate; Elmiron (TN); Xylan,hydrogen sulfate; [(2R,3R,4S,5R)-2-hydroxy-5-[(2S,3R,4S,5R)-5-hydroxy-3,4-disulfooxyoxan-2-yl]oxy-3-sulfooxyoxan-4-yl] hydrogen sulfate
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Drug Type |
Small molecular drug
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Indication | Interstitial cystitis; Painful bladder syndrome [ICD9: 595.1,338,780; ICD10:N30.1, G89, R52] | Approved | [538539] | ||
Therapeutic Class |
Anticoagulants
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Company |
Ortho-McNeil Pharmaceutical
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Structure |
Download2D MOL |
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Formula |
C10H18O21S4
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Canonical SMILES |
C1C(C(C(C(O1)OC2COC(C(C2OS(=O)(=O)O)OS(=O)(=O)O)O)OS(=O<br />)(=O)O)OS(=O)(=O)O)O
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InChI |
1S/C10H18O21S4/c11-3-1-26-10(8(31-35(22,23)24)5(3)28-32(13,14)15)27-4-2-25-9(12)7(30-34(19,20)21)6(4)29-33(16,17)18/h3-12H,1-2H2,(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,23,24)/t3-,4-,5+,6+,7-,8-,9-,10+/m1/s1
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InChIKey |
FCCNSUIJIOOXEZ-SJYYZXOBSA-N
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CAS Number |
CAS 37300-21-3
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
SuperDrug ATC ID |
B01AX06
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SuperDrug CAS ID |
cas=140207938
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Target and Pathway | |||||
Target(s) | Fibroblast growth factor-4 | Target Info | Modulator | [556264] | |
PANTHER Pathway | FGF signaling pathway | ||||
Pathway Interaction Database | Regulation of nuclear beta catenin signaling and target gene transcription | ||||
FGF signaling pathway | |||||
Reactome | PI3K Cascade | ||||
PIP3 activates AKT signaling | |||||
FGFR4 ligand binding and activation | |||||
FGFR3c ligand binding and activation | |||||
FGFR2c ligand binding and activation | |||||
FGFR3 mutant receptor activation | |||||
Activated point mutants of FGFR2 | |||||
Constitutive Signaling by Aberrant PI3K in Cancer | |||||
Phospholipase C-mediated cascade: FGFR1 | |||||
Phospholipase C-mediated cascade | |||||
Phospholipase C-mediated cascade | |||||
Phospholipase C-mediated cascade | |||||
SHC-mediated cascade:FGFR1 | |||||
PI-3K cascade:FGFR1 | |||||
FRS-mediated FGFR1 signaling | |||||
PI-3K cascade:FGFR2 | |||||
SHC-mediated cascade:FGFR2 | |||||
FRS-mediated FGFR2 signaling | |||||
SHC-mediated cascade:FGFR3 | |||||
FRS-mediated FGFR3 signaling | |||||
PI-3K cascade:FGFR3 | |||||
FRS-mediated FGFR4 signaling | |||||
SHC-mediated cascade:FGFR4 | |||||
PI-3K cascade:FGFR4 | |||||
Negative regulation of FGFR1 signaling | |||||
Negative regulation of FGFR2 signaling | |||||
Negative regulation of FGFR3 signaling | |||||
Negative regulation of FGFR4 signaling | |||||
RAF/MAP kinase cascade | |||||
References |
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