Drug General Information
Drug ID	D0F5TA
Former ID	DNC012034
Drug Name	Ethyl-indol-1-yl-pyridin-4-yl-amine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534087]
Structure		Download 2D MOL 3D MOL
Formula	C15H15N3
Canonical SMILES	CCN(C1=CC=NC=C1)N2C=CC3=CC=CC=C32
InChI	1S/C15H15N3/c1-2-17(14-7-10-16-11-8-14)18-12-9-13-5-3-4-6-15(13)18/h3-12H,2H2,1H3
InChIKey	RBKZPZVPVZNIMS-UHFFFAOYSA-N
PubChem Compound ID	10561859
Target and Pathway
Target(s)	Alpha-2C adrenergic receptor	Target Info	Inhibitor	[534087]
	Alpha-2A adrenergic receptor	Target Info	Inhibitor	[534087]
	Alpha-2B adrenergic receptor	Target Info	Inhibitor	[534087]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolismR-HSA-390696:Adrenoceptors
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	GPCR downstream signaling
References
Ref 534087	J Med Chem. 1996 Jan 19;39(2):570-81.Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.
Ref 534087	J Med Chem. 1996 Jan 19;39(2):570-81.Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.