Drug Information

Drug General Information
Drug ID
D0F4SY
Former ID
DIB014244
Drug Name
Pridopidine
Synonyms
Huntexil; Pridopidine hydrochloride; ACR-16; ASP-2314; Dopamine modulator (Huntingtons disease), Carlsson Research; Dopamine modulator (Huntingtons disease), NeuroSearch; Dopamine modulator (schizophrenia), Astellas; Dopamine modulator (schizophrenia), Fujisawa; Dopamine modulator (neurological disorders), Merck & Co
Drug Type
Small molecular drug
Indication Huntington's disease [ICD9: 294.1, 333.4; ICD10:F02.2, G10] Phase 3 [522303]
Company
Teva pharmaceutical
Structure
Download
2D MOL

3D MOL
Formula
C15H23NO2S
Canonical SMILES
S(=O)(=O)(c1cc(C2CCN(CC2)CCC)ccc1)C
CAS Number
CAS 346688-38-8
PubChem Compound ID
9795739
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Modulator [531022]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 522303ClinicalTrials.gov (NCT00665223) A Study of Treatment With ACR16 in Patients With Huntington's Disease. U.S. National Institutes of Health.
Ref 531022Efficacy and safety of the dopaminergic stabilizer Pridopidine (ACR16) in patients with Huntington's disease. Clin Neuropharmacol. 2010 Sep-Oct;33(5):260-4.

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