Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0F4HJ
|
||||
| Former ID |
DIB016874
|
||||
| Drug Name |
5-HT 6 antagonists
|
||||
| Synonyms |
IDDBCP245491
|
||||
| Indication | Obesity [ICD9: 278; ICD10:E66] | Investigative | [1] | ||
| Company |
Bristol-Myers Squibb Co
|
||||
| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
c1cccc(c1)S(=O)(=O)c1c(nc2n(c1=N)cccc2)SC
|
||||
| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 6 receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| PathWhiz Pathway | Excitatory Neural Signalling Through 5-HTR 6 and Serotonin | ||||
| Reactome | Serotonin receptors | ||||
| G alpha (s) signalling events | |||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Identification of a potent and selective 5-HT(6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile. J Med Chem. 2003 Nov 6;46(23):4834-7. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 11). | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.