Drug Information

Drug General Information
Drug ID
D0F2XV
Former ID
DAP000117
Drug Name
Aztreonam
Synonyms
Azactam; Primbactam; Azactam (TN); SQ-26776; Monobactam, SQ 26776, Squibb 26776, Aztreonam; [2S-[2alpha,3beta(Z)]]-2-[[[1-(2-Amino-4-thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid; 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-{[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino}-2-oxoethylidene]amino}oxy)-2-methylpropanoic acid; 2-[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxy-2-methylpropanoic acid
Drug Type
Small molecular drug
Indication Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Approved [536361]
Therapeutic Class
Antibiotics
Company
Bristol-Myers Squibb Company
Structure
Download
2D MOL

3D MOL
Formula
C13H17N5O8S2
Canonical SMILES
CC1C(C(=O)N1S(=O)(=O)O)NC(=O)C(=NOC(C)(C)C(=O)O)C2=CSC(<br />=N2)N
InChI
1S/C13H17N5O8S2/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25)/b17-8-/t5-,7-/m0/s1
InChIKey
WZPBZJONDBGPKJ-VEHQQRBSSA-N
CAS Number
CAS 78110-38-0
PubChem Compound ID
5742832
PubChem Substance ID
503035, 605760, 7978752, 8142308, 10321853, 11765528, 12013309, 14783375, 14930214, 39538698, 47871110, 48020413, 48244800, 48395280, 48415600, 49698380, 50124378, 50768269, 57365010, 85787954, 91652037, 92125075, 92309205, 92713785, 93166923, 103220466, 103914334, 104098313, 104253180, 114107021, 119526244, 121362746, 124757300, 125164104, 126624596, 126655874, 135692167, 136368064, 136949096, 139813750, 143491685, 144115675, 151979576, 152101196, 152242936, 160871057, 162037635, 164787753, 170496669, 174549401
ChEBI ID
ChEBI:2960
SuperDrug ATC ID
J01DF01
SuperDrug CAS ID
cas=078110380
Target and Pathway
Target(s) Penicillin binding protein 3 Target Info Binder [535671]
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 535671Penicillin-binding protein PBP2 of Escherichia coli localizes preferentially in the lateral wall and at mid-cell in comparison with the old cell pole. Mol Microbiol. 2003 Jan;47(2):539-47.

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