Drug Information

Drug General Information
Drug ID
D0EV8E
Former ID
DAP001269
Drug Name
Econazole
Synonyms
Ecostatin; Palavale; Pevaryl; Ecostatin Vaginal Ovules; Ecostatin cream; Spectazole cream; SQ 13050; Ecostatin (TN); Gyno-Pevaryl 150; Gyno-pevaryl; Pevaryl (TN); Spectazole (TN); Econazole (USAN/INN); 1-[2,4-Dichloro-.beta.-[(p-chlorobenzyl)oxy]phenethyl]imidazole; 1-[2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole; 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole; 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole; 1-{2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole; 1-{2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
Drug Type
Small molecular drug
Indication Tinea pedis; Tinea cruris; Tinea corporis; Cutaneous candidiasis; Tinea versicolor [ICD10:B353] Approved [551871]
Chronic pain [ICD9: 338.2,780; ICD10:R52.1-R52.2, G89] Phase 3 [532876]
Therapeutic Class
Antifungal Agents
Company
Merz Pharmaceuticals Llc
Structure
Download
2D MOL

3D MOL
Formula
C18H15Cl3N2O
InChI
InChI=1S/C18H15Cl3N2O/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2
InChIKey
LEZWWPYKPKIXLL-UHFFFAOYSA-N
CAS Number
CAS 27220-47-9
PubChem Compound ID
3198
PubChem Substance ID
10268, 448079, 603851, 7440588, 7979146, 8152035, 11335288, 11360527, 11364117, 11366679, 11369241, 11372592, 11373971, 11377403, 11405957, 11406340, 11461499, 11466332, 11467452, 11485314, 11486223, 11489255, 11491282, 11492261, 11495037, 14829428, 29222340, 46508881, 47205924, 47440102, 47515167, 47736313, 48034959, 48184847, 48334335, 48334336, 49698924, 50077661, 53787959, 56312807, 56313676, 56314323, 57321659, 79476142, 85173352, 85240399, 85788404, 92711383, 103212333, 104024743
ChEBI ID
ChEBI:4754
SuperDrug ATC ID
D01AC03; G01AF05
SuperDrug CAS ID
cas=027220479
Target and Pathway
Target(s) Fungal Cytochrome P450 51 Target Info Inhibitor [536809]
References
Ref 532876Econazole nitrate foam 1% for the treatment of tinea pedis: results from two double-blind, vehicle-controlled, phase 3 clinical trials. J Drugs Dermatol. 2014 Jul;13(7):803-8.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536809Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. Antimicrob Agents Chemother. 2008 Oct;52(10):3597-603. Epub 2008 Aug 11.

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