Drug Information

Drug General Information
Drug ID
D0E8UO
Former ID
DAP001194
Drug Name
Urokinase
Indication Deep venous thrombosis; Pulmonary embolism; Myocardial infarction [ICD9: 410, 415.1, 437.6, 444.9, 453, 453.40, 671.5, 671.9; ICD10:I21, I22, I26, I74, I80-I82, I80.2, I82, O88, T79.0-T79.1] Approved [536186]
Therapeutic Class
Thrombolytic Agents
Formula
C1376H2145N383O406S18
CAS Number
CAS 9039-53-6
SuperDrug ATC ID
B01AD04
Target and Pathway
Target(s) Urokinase-type plasminogen activator Target Info Modulator [556264]
KEGG Pathway NF-kappa B signaling pathway
Complement and coagulation cascades
Transcriptional misregulation in cancer
Proteoglycans in cancer
MicroRNAs in cancer
NetPath Pathway IL2 Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Blood coagulation
Plasminogen activating cascade
CCKR signaling map ST
Pathway Interaction Database Beta1 integrin cell surface interactions
E2F transcription factor network
Beta3 integrin cell surface interactions
Osteopontin-mediated events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
amb2 Integrin signaling
ATF-2 transcription factor network
AP-1 transcription factor network
Beta2 integrin cell surface interactions
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
FGF signaling pathway
Reactome Dissolution of Fibrin Clot
WikiPathways DNA Damage Response (only ATM dependent)
Senescence and Autophagy in Cancer
Complement and Coagulation Cascades
Endochondral Ossification
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
Blood Clotting Cascade
Dissolution of Fibrin Clot
Osteopontin Signaling
References
Ref 536186Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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