Drug Information

Drug General Information
Drug ID
D0E6OC
Former ID
DAP001531
Drug Name
Tranilast
Synonyms
Rizaben; Tranilastum; MK 341; T 0318; NU-3450; Rizaben (TN); SB-252218; Tranilastum [INN-Latin]; Tranilast [USAN:INN:JAN]; Tranilast (JAN/USAN/INN); N-(3,4-Dimethoxycinnamoyl)anthranilic acid; Rizaben, SB 252218, MK 341, Tranpro ,Tranilast; N-(3',4'-dimethoxycinnamoyl) anthranilic acid; N-(3′,4′-Dimethoxycinnamoyl)anthranilic Acid; 2-((3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl)amino)benzoic acid; 2-({(2E)-3-[3,4-bis(methyloxy)phenyl]prop-2-enoyl}amino)benzoic acid; 2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid; 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino] benzoic acid; 3,4-DAA
Drug Type
Small molecular drug
Indication Ocular allergy [ICD9: 360-379; ICD10:H00-H59] Approved [536119], [541472]
Company
Kissei
Structure
Download
2D MOL

3D MOL
Formula
C18H17NO5
InChI
InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
InChIKey
NZHGWWWHIYHZNX-CSKARUKUSA-N
CAS Number
CAS 53902-12-8
PubChem Compound ID
5282230
PubChem Substance ID
855567, 7849089, 8616956, 12013287, 14801725, 17405845, 24278719, 26612911, 26680238, 26719641, 26759646, 39315705, 46386750, 47589114, 47810891, 47885539, 48416652, 49645767, 49684379, 49700724, 49887093, 50103918, 50103919, 50103920, 53778299, 56422140, 57288861, 57358583, 75624513, 85231347, 85789432, 87870631, 89850281, 90341124, 92303237, 92308202, 92308335, 92308903, 92711430, 99437152, 99444086, 103330746, 107388281, 113856723, 118303066, 121362071, 124637814, 124757248, 124799410, 124883425
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [536119]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 536119Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20.
Ref 541472(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6326).
Ref 536119Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20.

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