Drug Information

Drug General Information
Drug ID
D0E4VQ
Former ID
DIB008669
Drug Name
Beloranib
Synonyms
CKD-731; CKD-732; Fumagillin analogs, Chong Kun Dang; HRK-429; HRK-512
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 3 [524814], [543139]
Company
Zafgen
Structure
Download
2D MOL

3D MOL
Formula
C29H41NO6
InChI
InChI=1S/C29H41NO6/c1-20(2)7-13-24-28(3,36-24)27-26(32-6)23(15-16-29(27)19-34-29)35-25(31)14-10-21-8-11-22(12-9-21)33-18-17-30(4)5/h7-12,14,23-24,26-27H,13,15-19H2,1-6H3/b14-10+/t23-,24-,26-,27-,28+,29+/m1/s1
InChIKey
ZEZFKUBILQRZCK-MJSCXXSSSA-N
PubChem Compound ID
6918502
PubChem Substance ID
14786481, 17194927, 43529872, 56472465, 74585909, 114788069, 135263384, 137640596, 198950332, 239625642, 252166655
Target and Pathway
Target(s) Methionine aminopeptidase 2 Target Info Inhibitor [532701]
Reactome Inactivation, recovery and regulation of the phototransduction cascade
References
Ref 524814ClinicalTrials.gov (NCT02179151) Double-Blind, Placebo Controlled, Phase 3 Trial of ZGN-440 (Beloranib) in Obese Subjects With Prader-Willi Syndrome. U.S. National Institutes of Health.
Ref 543139(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8445).
Ref 532701Inhibition of the methionine aminopeptidase 2 enzyme for the treatment of obesity. Diabetes Metab Syndr Obes. 2014 Feb 28;7:73-84.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.