Drug Information

Drug General Information
Drug ID
D0E3FR
Former ID
DIB020372
Drug Name
ML297
Synonyms
ML-297; ML 297
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542720]
Structure
Download
2D MOL
Formula
C17H14F2N4O
InChI
InChI=1S/C17H14F2N4O/c1-11-9-16(23(22-11)13-5-3-2-4-6-13)21-17(24)20-12-7-8-14(18)15(19)10-12/h2-10H,1H3,(H2,20,21,24)
InChIKey
IEKSMUSSYJUQMY-UHFFFAOYSA-N
PubChem Compound ID
56642816
PubChem Substance ID
134418959, 135363148, 144098638, 169551235, 170485780, 174487363, 175450300, 223366101, 249896080, 252158813, 252450718, 252664624
Target and Pathway
Target(s) Potassium channel KCNJ3 Kir3.1 Target Info Activator [532382]
KEGG Pathway Circadian entrainment
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Estrogen signaling pathway
Oxytocin signaling pathway
Morphine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
GABA-B receptor II signaling
PathWhiz Pathway Muscle/Heart Contraction
Reactome Activation of G protein gated Potassium channels
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways Calcium Regulation in the Cardiac Cell
G Protein Signaling Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Potassium Channels
References
Ref 542720(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7768).
Ref 532382ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem Neurosci. 2013 Sep 18;4(9):1278-86.

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