Drug Information
Drug General Information | |||||
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Drug ID |
D0DC3E
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Former ID |
DNC009349
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Drug Name |
3,3'-pyrazine-2,5-diyldiphenol
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [529748] | ||
Structure |
Download2D MOL |
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Formula |
C16H12N2O2
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Canonical SMILES |
C1=CC(=CC(=C1)O)C2=CN=C(C=N2)C3=CC(=CC=C3)O
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InChI |
1S/C16H12N2O2/c19-13-5-1-3-11(7-13)15-9-18-16(10-17-15)12-4-2-6-14(20)8-12/h1-10,19-20H
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InChIKey |
NBGGRQZLXLTPFA-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Estradiol 17 beta-dehydrogenase 1 | Target Info | Inhibitor | [529748] | |
NetPath Pathway | FSH Signaling Pathway | ||||
PANTHER Pathway | Androgen/estrogene/progesterone biosynthesis | ||||
PathWhiz Pathway | Androgen and Estrogen Metabolism | ||||
References | |||||
Ref 529748 | J Med Chem. 2008 Nov 13;51(21):6725-39. Epub 2008 Oct 15.Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1). | ||||
Ref 529748 | J Med Chem. 2008 Nov 13;51(21):6725-39. Epub 2008 Oct 15.Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1). |
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