Drug Information

Drug General Information
Drug ID
D0D9HW
Former ID
DAP000700
Drug Name
Tenofovir
Synonyms
Apropovir; PMPA; TFV; Tenefovir; GS 1275; GS 1278; GS1278; Atripla (TN); Emtriva (TN); GNA & Tenofovir; HHA & Tenofovir; KS-5021; Truvada (TN); Viread (TN); Viread, Tenofovir; D,L-Tenofovir; PMPA-(R); Phosphonic acid, [[2-(6-amino-9H-purin-9; [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid; Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-(9CI); Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-& Galanthus nivalis agglutinin (GNA); Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-& Hippeastrum hybrid agglutinin(HHA); (R)-9-(2-Phosphonomethoxypropyl)adenine; (R)-9-(2-Phosphonylmethoxypropyl)adenine; (R)-PMPA; TDF
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Approved [537238]
Therapeutic Class
Anti-HIV Agents
Company
Gilead Sciences
Structure
Download
2D MOL

3D MOL
Formula
C9H14N5O4P
Canonical SMILES
CC(CN1C=NC2=C1N=CN=C2N)OCP(=O)(O)O
InChI
1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1
InChIKey
SGOIRFVFHAKUTI-ZCFIWIBFSA-N
CAS Number
CAS 147127-20-6
PubChem Compound ID
464205
PubChem Substance ID
610434, 3727050, 3727057, 7980754, 10304546, 12014981, 14873257, 46508131, 48424314, 50112788, 50437671, 57405565, 92719253, 99437132, 102979961, 103169192, 109738216, 121362228, 124757224, 125164028, 126610616, 126628295, 126655803, 127310209, 127310210, 127339001, 127339002, 129233080, 134337989, 135078595, 135606020, 135611180, 135682533, 135698226, 136367764, 136372374, 136905481, 137005935, 141613622, 151996120, 152034360, 152165365, 152246774, 152344570, 160963648, 162184452, 162793588, 163658367, 163813066, 171563543
SuperDrug ATC ID
J05AF07
SuperDrug CAS ID
cas=201341051
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) HIV reverse transcriptase Target Info Inhibitor [535958]
References
Ref 537238Anti-hepatitis B virus activity in vitro of combinations of tenofovir with nucleoside/nucleotide analogues. Antivir Chem Chemother. 2009;19(4):165-76.
Ref 535958Antiviral drugs in current clinical use. J Clin Virol. 2004 Jun;30(2):115-33.

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