Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0D8TE
|
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| Former ID |
DIB014537
|
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| Drug Name |
FBS-0701
|
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| Synonyms |
Desferrithiocin analog (oral, iron overload), FerroKin Biosciences; Iron chelator (oral, iron overload), FerroKin Biosciences
|
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| Drug Type |
Small molecular drug
|
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| Indication | Iron overload [ICD10:R79.0] | Phase 2 | [1] | ||
| Company |
FerroKin BioSciences Inc
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C18H25NO7S
|
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| Canonical SMILES |
N1=C(c2cccc(c2O)OCCOCCOCCOC)SC[C@@]1(C(=O)O)C.[Mg](O)O
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Hemoglobin | Target Info | Modulator | [2] | |
| KEGG Pathway | African trypanosomiasis | ||||
| Malaria | |||||
| Reactome | Erythrocytes take up carbon dioxide and release oxygen | ||||
| Erythrocytes take up oxygen and release carbon dioxide | |||||
| Scavenging of heme from plasma | |||||
| WikiPathways | Binding and Uptake of Ligands by Scavenger Receptors | ||||
| Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | |||||
| Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes | |||||
| Factors involved in megakaryocyte development and platelet production | |||||
| Folate Metabolism | |||||
| Vitamin B12 Metabolism | |||||
| Selenium Micronutrient Network | |||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT01186419) Safety and Pharmacodynamic Study of an Oral Iron Chelator Given for 6 Months to Patients With Iron Overload. U.S. National Institutes of Health. | ||||
| REF 2 | A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma. Clin Cancer Res. 2009 Dec 1;15(23):7144-52. | ||||
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