Drug Information

Drug General Information
Drug ID
D0D5OY
Former ID
DIB018816
Drug Name
alpha-fluoromethylenephosphonate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539931]
Structure
Download
2D MOL
Formula
C23H44FO6P
InChI
InChI=1S/C23H44FO6P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(25)30-20-21(29-2)19-22(24)31(26,27)28/h10-11,21-22H,3-9,12-20H2,1-2H3,(H2,26,27,28)/b11-10+/t21-,22?/m0/s1
InChIKey
KGVHPTQYUKZZPY-VXECIVMWSA-N
PubChem Compound ID
44400349
PubChem Substance ID
90046982, 103463468, 135649923
Target and Pathway
Target(s) Lysophosphatidate-3 receptor Target Info Agonist [527535]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Pathways in cancer
Pathway Interaction Database LPA receptor mediated events
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 539931(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2915).
Ref 527535Structure-activity relationships of fluorinated lysophosphatidic acid analogues. J Med Chem. 2005 May 5;48(9):3319-27.

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