| Drug General Information |
| Drug ID |
D0D3YL
|
| Former ID |
DNC005644
|
| Drug Name |
(5-Phenyl-oxazol-2-yl)-m-tolyl-amine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C16H14N2O
|
| Canonical SMILES |
CC1=CC(=CC=C1)NC2=NC=C(O2)C3=CC=CC=C3
|
| InChI |
1S/C16H14N2O/c1-12-6-5-9-14(10-12)18-16-17-11-15(19-16)13-7-3-2-4-8-13/h2-11H,1H3,(H,17,18)
|
| InChIKey |
XLGKHWGSIZWZNN-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
mRNA of VEGFR1 |
Target Info |
Inhibitor |
[1]
|
|---|
| Vascular endothelial growth factor receptor 2 |
Target Info |
Inhibitor |
[1]
|
| Vascular endothelial growth factor receptor 3 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
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Ras signaling pathway
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Rap1 signaling pathway
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Cytokine-cytokine receptor interaction
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HIF-1 signaling pathway
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Endocytosis
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PI3K-Akt signaling pathway
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Focal adhesion
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Transcriptional misregulation in cancer
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Rheumatoid arthritishsa04014:Ras signaling pathway
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VEGF signaling pathway
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Proteoglycans in cancerhsa04014:Ras signaling pathway
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NetPath Pathway
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IL2 Signaling PathwayNetPath_9:TNFalpha Signaling Pathway
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PANTHER Pathway
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Angiogenesis
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VEGF signaling pathway
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Pathway Interaction Database
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Glypican 1 network
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HIF-2-alpha transcription factor network
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S1P3 pathway
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VEGF and VEGFR signaling network
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VEGFR1 specific signals
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Signaling events mediated by VEGFR1 and VEGFR2hif2pathway:HIF-2-alpha transcription factor network
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Beta3 integrin cell surface interactions
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Signaling events mediated by TCPTP
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SHP2 signaling
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S1P1 pathway
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Integrins in angiogenesis
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Signaling events mediated by VEGFR1 and VEGFR2
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Notch-mediated HES/HEY networkvegf_vegfr_pathway:VEGF and VEGFR signaling network
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VEGFR3 signaling in lymphatic endothelium
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Reactome
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Neurophilin interactions with VEGF and VEGFR
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VEGF binds to VEGFR leading to receptor dimerizationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
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VEGF binds to VEGFR leading to receptor dimerization
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Integrin cell surface interactions
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EPHA-mediated growth cone collapse
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VEGFA-VEGFR2 Pathway
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VEGFR2 mediated cell proliferationR-HSA-195399:VEGF binds to VEGFR leading to receptor dimerization
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WikiPathways
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Focal Adhesion
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Signaling by VEGF
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AngiogenesisWP306:Focal Adhesion
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Nifedipine Activity
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Cardiac Progenitor Differentiation
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AngiogenesisWP1919:Signaling by VEGF
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| References |
| REF 1 | J Med Chem. 2005 Mar 10;48(5):1610-9.Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. |
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