Drug Information
Drug General Information | |||||
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Drug ID |
D0D3ID
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Former ID |
DNC004037
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Drug Name |
GAMMA-AMINO-BUTANOIC ACID
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [528408] | ||
Structure |
Download2D MOL |
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Formula |
C4H9NO2
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Canonical SMILES |
C(CC(=O)O)CN
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InChI |
1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
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InChIKey |
BTCSSZJGUNDROE-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Gamma-aminobutyric acid receptor subunit gamma-2 | Target Info | Inhibitor | [528408] | |
Gamma-aminobutyric acid B receptor | Target Info | Inhibitor | [528071] | ||
GABA transporter-3 | Target Info | Inhibitor | [533538] | ||
Gamma-aminobutyric-acid receptor alpha-2 subunit | Target Info | Inhibitor | [533580] | ||
Gamma-aminobutyric-acid receptor alpha-3 subunit | Target Info | Inhibitor | [533580] | ||
Gamma-aminobutyric acid receptor | Target Info | Inhibitor | [528408] | ||
Gamma-aminobutyric acid receptor subunit beta-2 | Target Info | Inhibitor | [528408] | ||
Gamma-aminobutyric acid receptor subunit alpha-1 | Target Info | Inhibitor | [528408] | ||
Gamma-aminobutyric-acid receptor alpha-5 subunit | Target Info | Inhibitor | [533580] | ||
Sodium- and chloride-dependent GABA transporter 1 | Target Info | Inhibitor | [527271] | ||
KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
Retrograde endocannabinoid signaling | |||||
GABAergic synapse | |||||
Morphine addiction | |||||
Nicotine addictionhsa04024:cAMP signaling pathway | |||||
Estrogen signaling pathway | |||||
Morphine addictionhsa04080:Neuroactive ligand-receptor interaction | |||||
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction | |||||
Serotonergic synapse | |||||
Nicotine addictionhsa04727:GABAergic synapse | |||||
Reactome | Ligand-gated ion channel transport | ||||
GABA A receptor activationR-HSA-1296041:Activation of G protein gated Potassium channels | |||||
G alpha (i) signalling events | |||||
Class C/3 (Metabotropic glutamate/pheromone receptors) | |||||
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsR-HSA-975298:Ligand-gated ion channel transport | |||||
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport | |||||
GABA A receptor activationR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters | |||||
WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
Iron uptake and transportWP501:GPCRs, Class C Metabotropic glutamate, pheromone | |||||
Potassium Channels | |||||
GPCR ligand binding | |||||
GPCR downstream signalingWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
Iron uptake and transportWP706:SIDS Susceptibility Pathways | |||||
Iron uptake and transportWP727:Monoamine Transport | |||||
NRF2 pathway | |||||
References | |||||
Ref 527271 | J Med Chem. 2004 Nov 4;47(23):5620-9.Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling. | ||||
Ref 528071 | J Med Chem. 1991 Aug;34(8):2557-60.3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies. | ||||
Ref 528408 | J Med Chem. 2006 Sep 7;49(18):5571-7.3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. | ||||
Ref 533538 | J Med Chem. 1981 Jul;24(7):788-94.Epimeric cis-decahydroquinoline-5-carboxylic acids: effects on gamma-aminobutyric acid uptake and receptor binding in vitro. | ||||
Ref 533580 | J Med Chem. 1980 Jun;23(6):702-4.New anticonvulsants: Schiff bases of gamma-aminobutyric acid and gamma-aminobutyramide. |
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