Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0D1HA
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| Former ID |
DAP000146
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| Drug Name |
Cefotaxime
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| Synonyms |
Cefotaxim; Cefotaxima; Cefotaximum; Cephotaxim; Cephotaxime; Claforan; Klaforan; Cefotaxim Hikma; Cefotaxime acid; CE3; RU 24662; Cefotaxim Hikma (TN); Cefotaxima [INN-Spanish]; Cefotaxime (INN); Cefotaxime [INN:BAN]; Cefotaximum [INN-Latin]; Claforan (TN); Ru-24756; Claforan (*Sodium salt*)
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] | Approved | [538212] | ||
| Therapeutic Class |
Antibiotics
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| Company |
Roussel Uclaf
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| Structure |
|
Download2D MOL |
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| Formula |
C16H17N5O7S2
|
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| Canonical SMILES |
CC(=O)OCC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)N)SC1)C<br />(=O)O
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| InChI |
1S/C16H17N5O7S2/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26)
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| InChIKey |
GPRBEKHLDVQUJE-UHFFFAOYSA-N
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| CAS Number |
CAS 63527-52-6
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| SuperDrug ATC ID |
J01DD01
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| SuperDrug CAS ID |
cas=064485934
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| Target and Pathway | |||||
| Target(s) | D-alanyl-D-alanine carboxypeptidase | Target Info | Inhibitor | [536459], [537844] | |
| References | |||||
| Ref 536459 | Extended-spectrum cephalosporinases: structure, detection and epidemiology. Future Microbiol. 2007 Jun;2:297-307. | ||||
| Ref 537844 | Binding of cephalothin and cefotaxime to D-ala-D-ala-peptidase reveals a functional basis of a natural mutation in a low-affinity penicillin-binding protein and in extended-spectrum beta-lactamases. Biochemistry. 1995 Jul 25;34(29):9532-40. | ||||
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