Drug Information

Drug General Information
Drug ID
D0D1EE
Former ID
DNC007175
Drug Name
Ginkgolide J
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539174]
Structure
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2D MOL

3D MOL
Formula
C20H24O10
InChI
InChI=1S/C20H24O10/c1-6-12(23)27-7-5-17-11-8(21)9(16(2,3)4)18(17)10(22)13(24)29-15(18)30-20(17,14(25)28-11)19(6,7)26/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8-,9+,10?,11-,15+,17?,18?,19-,20-/m1/s1
InChIKey
LMEHVEUFNRJAAV-MHIVRBJNSA-N
CAS Number
CAS 107438-79-9
PubChem Compound ID
441296
PubChem Substance ID
9806, 74382530, 135652688, 137038585, 164814838, 179316259, 223439821
Target and Pathway
Target(s) Glycine receptor alpha-1 chain Target Info Inhibitor [528727]
Glycine receptor Target Info Inhibitor [528727]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Reactome Ligand-gated ion channel transportR-HSA-975298:Ligand-gated ion channel transport
WikiPathways Iron uptake and transport
References
Ref 539174(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1864).
Ref 528727J Med Chem. 2007 Apr 5;50(7):1610-7. Epub 2007 Mar 13.Probing the pharmacophore of ginkgolides as glycine receptor antagonists.

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