Drug Information

Drug General Information
Drug ID
D0D1BR
Former ID
DNCL002989
Drug Name
GS-7340
Synonyms
NtRTI
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Phase 2 [523854]
Company
Gilead Sciences
Structure
Download
2D MOL

3D MOL
Formula
C21H29N6O5P
Canonical SMILES
CC(C)OC(=O)C(C)NP(=O)(COC(C)CN1C=NC2=C1N=CN=C2N)OC3=CC=<br />CC=C3
InChI
1S/C21H29N6O5P/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24)/t15-,16+,33-/m1/s1
InChIKey
LDEKQSIMHVQZJK-GNGHXOLXSA-N
PubChem Compound ID
9574767
PubChem Substance ID
619402, 23997724, 44712813, 75150444, 136349973, 141071366, 141780939, 223577083, 238156686, 251973415
Target and Pathway
Target(s) HIV reverse transcriptase Target Info Inhibitor [527526]
References
Ref 523854ClinicalTrials.gov (NCT01565850) Safety and Efficacy of Darunavir/Cobicistat/Emtricitabine/GS-7340 Single Tablet Regimen Versus Cobicistat-boosted Darunavir Plus Emtricitabine/Tenofovir Disoproxil Fumarate Fixed Dose Combination in HIV-1 Infected, Antiretroviral Treatment Naive Adults. U.S. National Institutes of Health.
Ref 527526Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue. Antimicrob Agents Chemother. 2005 May;49(5):1898-906.

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