Drug General Information
Drug ID	D0D1BC
Former ID	DNC000922
Drug Name	Melanocortin-4 Receptor antagonist
Drug Type	Small molecular drug
Indication	Anorexia nervosa cachexia [ICD9: 307.1, 799.4; ICD10:F50.0-F50.1]		Investigative	[552046]
Company	Santhera
Structure		Download 2D MOL 3D MOL
Formula	C17H34O3
Canonical SMILES	COC(=O)CCCCCCCCCCCCCCCO
InChI	1S/C17H34O3/c1-20-17(19)15-13-11-9-7-5-3-2-4-6-8-10-12-14-16-18/h18H,2-16H2,1H3
InChIKey	AOTMRIXFFOGWDT-UHFFFAOYSA-N
PubChem Compound ID	3496888
PubChem Substance ID	4703469, 9727366, 16024205, 37315858, 75209162, 109614001, 112274827, 127437530, 162247445, 162510120, 224606343, 227474671, 249916014
Target and Pathway
Target(s)	Melanocortin-4 receptor	Target Info	Antagonist	[536225]
KEGG Pathway	Neuroactive ligand-receptor interaction
Pathway Interaction Database	Syndecan-3-mediated signaling events
Reactome	Peptide ligand-binding receptors
	G alpha (s) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 552046	Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774
Ref 536225	Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36.

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