Drug General Information
Drug ID	D0CO9Z
Former ID	DIB001092
Drug Name	Edg5 antagonists
Synonyms	Edg5 antagonists, Merck; Sphingosine 1-phosphate 2 antagonist (hypertension), Merck
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Investigative	[552105]
Company	Merck & Co Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C1N2C(N(C1)C(=O)c1ccccc1Oc1ccccc1)C(=O)N(CC2=O)Cc1c2c(c<br />cc1)cccc2
Target and Pathway
Target(s)	Sphingosine-1-phosphate receptor-2	Target Info	Antagonist	[543702]
KEGG Pathway	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interaction
Pathway Interaction Database	S1P3 pathway
	Sphingosine 1-phosphate (S1P) pathway
	S1P2 pathway
Reactome	G alpha (i) signalling events
	Lysosphingolipid and LPA receptors
WikiPathways	Signal Transduction of S1P Receptor
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 552105	Sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditions. PLoS One. 2011;6(8):e23905
Ref 543702	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 276).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.