Drug General Information
Drug ID
D0CI9T
Former ID
DCL000744
Drug Name
Ceftobiprole
Synonyms
BAL 9141; BAL 9141-000; BAL-9141; Ro 63-9141; Ro-63-9141; Ro-63-9141/000; (6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-ylidene)-2-nitrosoacetyl]amino]-8-oxo-3-[(E)-[2-oxo-1-[(3R)-pyrrolidin-3-yl]pyrrolidin-3-ylidene]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Drug Type
Small molecular drug
Indication Intensive care unit; Bacterial infections [ICD9: 001-009, 001-139, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Phase 1 [536773]
Company
Johnson & Johnson
Structure
Download
2D MOL

3D MOL

Formula
C20H22N8O6S2
Canonical SMILES
C1CNCC1N2CCC(=CC3=C(N4C(C(C4=O)NC(=O)C(=C5NSC(=N5)N)N=O<br />)SC3)C(=O)O)C2=O
InChI
1S/C20H22N8O6S2/c21-20-24-14(26-36-20)11(25-34)15(29)23-12-17(31)28-13(19(32)33)9(7-35-18(12)28)5-8-2-4-27(16(8)30)10-1-3-22-6-10/h5,10,12,18,22,26H,1-4,6-7H2,(H2,21,24)(H,23,29)(H,32,33)/b8-5+,14-11-/t10-,12-,18-/m1/s1
InChIKey
LXLDMYXULSBRCX-HZEONMFJSA-N
CAS Number
CAS 209467-52-7
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Bacterial penicillin binding protein Target Info Modulator [552696]
References
Ref 536773How many modes of action should an antibiotic have? Curr Opin Pharmacol. 2008 Oct;8(5):564-73. Epub 2008 Jul 30.
Ref 552696Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. Antimicrob Agents Chemother. 2007 Jul;51(7):2621-4. Epub 2007 Apr 30.

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