Drug Information

Drug General Information
Drug ID
D0CA6J
Former ID
DAP001268
Drug Name
Tioconazole
Synonyms
Fungibacid; GyneCure; Tioconazol; Tioconazolum; Trosyd; Trosyl; Vagistat; Zoniden; Trosyd AF; Trosyd J; Monistat 1; UK 20349; Gyno-trosyd; Tioconazol [INN-Spanish]; Tioconazolum [INN-Latin]; Tz-3; UK 20,349; UK-20349; Vagistat-1; Vagistat-1 (TN); Tioconazole (JAN/USP/INN); Tioconazole [USAN:BAN:INN:JAN]; (+-)-1-(2,4-Dichloro-beta-((2-chloro-3-ethenyl)oxy)phenethyl)imidazole; (+-)-1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole; 1-(2,4-Dichloro-(beta-(2-chloro-3-thenyl)oxy)phenethyl)imidazole; 1-(2,4-Dichloro-beta-((2-chloro-3-thenyl)-oxy)phenethyl)imidazole; 1-[2-[(2-chlorothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
Drug Type
Small molecular drug
Indication Onychomycosis [ICD10:B35.1] Approved [538305], [551871]
Therapeutic Class
Antifungal Agents
Structure
Download
2D MOL

3D MOL
Formula
C16H13Cl3N2OS
Canonical SMILES
C1=CC(=C(C=C1Cl)Cl)C(CN2C=CN=C2)OCC3=C(SC=C3)Cl
InChI
1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2
InChIKey
QXHHHPZILQDDPS-UHFFFAOYSA-N
CAS Number
CAS 65899-73-2
PubChem Compound ID
5482
PubChem Substance ID
10282, 603903, 5653393, 7847954, 7980798, 8153370, 12013844, 14927524, 29224526, 46508604, 49979374, 50112684, 50991121, 57322801, 92308141, 92309028, 92712535, 103770421, 104309359, 119526232, 124766203, 124893309, 125355655, 126630084, 126685353, 129088346, 131322824, 134338504, 135007299, 135692331, 136949628, 143350892, 144075907, 144205987, 152045919, 160849320, 160964343, 162177689, 163138380, 164175132, 164814551, 170465343, 174007147, 175611158, 176484485, 179116921, 184021117, 184545064, 185984694, 187072606
SuperDrug ATC ID
D01AC07; G01AF08
SuperDrug CAS ID
cas=065899732
Target and Pathway
Target(s) Fungal Cytochrome P450 51 Target Info Inhibitor [536031]
References
Ref 538305FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 075915.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536031Biological spectra analysis: Linking biological activity profiles to molecular structure. Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):261-6. Epub 2004 Dec 29.

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