| Drug General Information |
| Drug ID |
D0C9VH
|
| Former ID |
DNC012363
|
| Drug Name |
N-(4-Dimethylamino-but-2-ynyl)-N-methyl-acetamide
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C9H16N2O
|
| Canonical SMILES |
CC(=O)N(C)CC#CCN(C)C
|
| InChI |
1S/C9H16N2O/c1-9(12)11(4)8-6-5-7-10(2)3/h7-8H2,1-4H3
|
| InChIKey |
FPUURHVXHFAVKC-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Muscarinic acetylcholine receptor M4 |
Target Info |
Inhibitor |
[1]
|
|---|
| Muscarinic acetylcholine receptor M5 |
Target Info |
Inhibitor |
[1]
|
| Muscarinic acetylcholine receptor M1 |
Target Info |
Inhibitor |
[1]
|
| Muscarinic acetylcholine receptor M2 |
Target Info |
Inhibitor |
[1]
|
| Muscarinic acetylcholine receptor M3 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Neuroactive ligand-receptor interaction
|
|
Cholinergic synapse
|
|
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
|
|
cAMP signaling pathway
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PI3K-Akt signaling pathway
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Regulation of actin cytoskeleton
|
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Insulin secretion
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Salivary secretion
|
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Gastric acid secretion
|
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Pancreatic secretion
|
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PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
|
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Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
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Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
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Muscarinic acetylcholine receptor 1 and 3 signaling pathway
|
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PathWhiz Pathway
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Muscle/Heart ContractionPW000565:Gastric Acid Production
|
|
Reactome
|
Muscarinic acetylcholine receptors
|
|
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
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G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
|
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Acetylcholine regulates insulin secretion
|
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G alpha (q) signalling events
|
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WikiPathways
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Monoamine GPCRs
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Calcium Regulation in the Cardiac Cell
|
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Regulation of Actin Cytoskeleton
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signalingWP58:Monoamine GPCRs
|
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Gastrin-CREB signalling pathway via PKC and MAPK
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Secretion of Hydrochloric Acid in Parietal Cells
|
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GPCR downstream signalingWP706:SIDS Susceptibility Pathways
|
|
GPCR downstream signaling
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GPCRs, OtherWP58:Monoamine GPCRs
|
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Integration of energy metabolism
|
|
GPCRs, Other
|
| References |
| REF 1 | Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992). |
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