Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0C9KD
|
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| Former ID |
DNC007086
|
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| Drug Name |
HOMOEPIBATIDINE
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Terminated | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C12H15ClN2
|
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| Canonical SMILES |
C1CC2CC(C(C1)N2)C3=CN=C(C=C3)Cl.Cl.Cl
|
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| InChI |
1S/C12H15ClN2.2ClH/c13-12-5-4-8(7-14-12)10-6-9-2-1-3-11(10)15-9;;/h4-5,7,9-11,15H,1-3,6H2;2*1H
|
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| InChIKey |
QPEBQSQMNCADEL-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Neuronal acetylcholine receptor protein, alpha-4 chain | Target Info | Inhibitor | [2] | |
| Neuronal acetylcholine receptor protein, beta-2 chain | Target Info | Inhibitor | [2] | ||
| Neuronal acetylcholine receptor protein, beta-4 chain | Target Info | Inhibitor | [2] | ||
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Cholinergic synapse | |||||
| Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction | |||||
| PANTHER Pathway | Nicotinic acetylcholine receptor signaling pathway | ||||
| Nicotine pharmacodynamics pathwayP00044:Nicotinic acetylcholine receptor signaling pathway | |||||
| Nicotine pharmacodynamics pathway | |||||
| Reactome | Highly sodium permeable acetylcholine nicotinic receptors | ||||
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | |||||
| Highly calcium permeable nicotinic acetylcholine receptorsR-HSA-629587:Highly sodium permeable acetylcholine nicotinic receptors | |||||
| Highly calcium permeable nicotinic acetylcholine receptors | |||||
| WikiPathways | SIDS Susceptibility Pathways | ||||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| Nicotine Activity on Dopaminergic NeuronsWP706:SIDS Susceptibility Pathways | |||||
| Nicotine Activity on Chromaffin Cells | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007531) | ||||
| REF 2 | Bioorg Med Chem Lett. 2006 Nov 1;16(21):5493-7. Epub 2006 Aug 28.Epibatidine isomers and analogues: structure-activity relationships. | ||||
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