Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0C8PI
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| Former ID |
DIB008578
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| Drug Name |
Zoniporide hydrochloride
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| Synonyms |
CP-597396; EMD-392426; Zoniporide hydrochloride < Prop INNM; N''-[5-Cyclopropyl-1-(5-quinolyl)-1H-pyrazol-4-ylcarbonyl]guanidine hydrochloride monohydrate
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| Drug Type |
Small molecular drug
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| Indication | Angina pectoris [ICD9: 413; ICD10:I20] | Phase 3 | [526547] | ||
| Structure |
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Download2D MOL |
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| Formula |
C17H17ClN6O
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| Canonical SMILES |
C1CC1C2=C(C=NN2C3=CC=CC4=C3C=CC=N4)C(=O)N=C(N)N.Cl
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| InChI |
1S/C17H16N6O.ClH/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);1H
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| InChIKey |
JTEXNYIOROVPIR-UHFFFAOYSA-N
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| CAS Number |
CAS 241800-97-5
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Sodium/hydrogen exchanger 1 | Target Info | Inhibitor | [526547], [531635] | |
| Pathway Interaction Database | Endothelins | ||||
| RhoA signaling pathway | |||||
| ErbB1 downstream signaling | |||||
| Signaling mediated by p38-alpha and p38-beta | |||||
| Reactome | Hyaluronan uptake and degradation | ||||
| References | |||||
| Ref 526547 | Zoniporde: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1). Cardiovasc Drug Rev. 2003 Spring;21(1):17-32. | ||||
| Ref 531635 | Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36. | ||||
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