Drug General Information
Drug ID	D0C6QQ
Former ID	DIB016758
Drug Name	Besipirdine
Synonyms	Besipirdine hydrochloride; HP-749; P-7480; P86-7480
Drug Type	Small molecular drug
Indication	Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3]		Phase 3	[550094]
Company	Hoechst Marion Roussel Inc
Structure		Download 2D MOL 3D MOL
Formula	C16H17N3
Canonical SMILES	n1(ccc2c1cccc2)N(c1ccncc1)CCC
PubChem Compound ID	60691
Target and Pathway
Target(s)	Alpha-1A adrenergic receptor	Target Info	Antagonist	[534361]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	AMPK signaling pathway
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretion
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
Reactome	Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Endothelin Pathways
	GPCR ligand binding
	GPCR downstream signaling
	AMPK Signaling
References
Ref 550094	Clinical pipeline report, company report or official report of UroGene.
Ref 534361	Alpha-Adrenergic activity and cardiovascular effects of besipirdine HCl (HP 749) and metabolite P7480 in vitro and in the conscious rat and dog. J Pharmacol Exp Ther. 1997 Apr;281(1):337-46.

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