Drug Information

Drug General Information
Drug ID
D0C6NM
Former ID
DAP001216
Drug Name
Latanoprost
Synonyms
Catioprost; Xalatan; Latanoprost free acid; L1167_SIGMA; PhXA41; XA41; AR-202; Nova-21027; PHXA-41; XA-41; Xalatan (TN); Latanoprost (JAN/USAN/INN); PhXA34 [as 15(R,S)-isomer]; Isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinorprost-5-en-1-oate; Isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinor-prost-5-en-1-oate; Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate; Propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate; Propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
Drug Type
Small molecular drug
Indication Open-angle glaucoma; Ocular hypertension [ICD9: 365, 365.04; ICD10:H40-H42, H40.0] Approved [536361], [539258]
Glaucoma [ICD9: 365; ICD10:H40-H42] Phase 2 [551115]
Glaucoma [ICD9: 365; ICD10:H40-H42] Phase 1/2 [551493]
Therapeutic Class
Antihypertensive Agents
Company
Pfizer Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C23H34O5
InChI
InChI=1S/C23H34O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,18-22,24-26H,2,7,10-16H2,(H,27,28)/b6-1-/t18-,19+,20+,21-,22+/m0/s1
InChIKey
HNPFPERDNWXAGS-NFVOFSAMSA-N
CAS Number
CAS 130209-82-4
PubChem Compound ID
6441636
PubChem Substance ID
11968815, 14829941, 24724524, 29217578, 43034285, 56311305, 57369233, 75823169, 103286196, 114563873, 118842177, 135124962, 135611159, 135650508, 142805251, 164228148, 198989236, 224405006, 227536373, 241078678, 252421418, 252457330, 252562137
ChEBI ID
ChEBI:6384
SuperDrug ATC ID
S01EE01
SuperDrug CAS ID
cas=130209824
Target and Pathway
Target(s) Prostaglandin F2-alpha receptor Target Info Agonist [537255]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 539258(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1961).
Ref 551115Clinical pipeline report, company report or official report of Mati therapeutics.
Ref 551493Clinical pipeline report, company report or official report of Pfizer.
Ref 537255PGF(2alpha) FP Receptor Contributes to Brain Damage Following Transient Focal Brain Ischemia. Neurotox Res. 2009 Jan;15(1):62-70. Epub 2009 Feb 11.

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