Drug General Information
Drug ID	D0C5NP
Former ID	DND000036
Drug Name	AGG-523
Synonyms	PF-5212371, WAY-266523
Indication	Osteoarthritis [ICD9: 715; ICD10:M15-M19, M47]		Phase 1	[521997]
Company	Pfizer
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Aggrecanase	Target Info	Inhibitor	[531304]
Reactome	Degradation of the extracellular matrix
	O-glycosylation of TSR domain-containing proteins
WikiPathways	Endochondral Ossification
	Vitamin D Receptor Pathway
References
Ref 521997	ClinicalTrials.gov (NCT00454298) Study Evaluating AGG-523 in Subjects With Severe Osteoarthritis Requiring Total Knee Replacement. U.S. National Institutes of Health.
Ref 531304	Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor. Osteoarthritis Cartilage. 2011 Mar;19(3):315-23.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.