Drug Information

Drug General Information
Drug ID
D0C2UY
Former ID
DNC003506
Drug Name
MANUMYCIN A
Drug Type
Small molecular drug
Indication Discovery agent Terminated [546113]
Structure
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2D MOL

3D MOL
Formula
C31H38N2O7
Canonical SMILES
CCCCC(C)C=C(C)C=C(C)C(=O)NC1=CC(C2C(C1=O)O2)(C=CC=CC=CC<br />(=O)NC3=C(CCC3=O)O)O
InChI
1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28-,29-,31+/m1/s1
InChIKey
TWWQHCKLTXDWBD-MVTGTTCWSA-N
PubChem Compound ID
6438330
Target and Pathway
Target(s) Farnesyltransferase Target Info Inhibitor [526603]
Protein farnesyltransferase beta subunit Target Info Inhibitor [526603]
KEGG Pathway Terpenoid backbone biosynthesis
Biosynthesis of antibioticshsa00900:Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
NetPath Pathway TSH Signaling Pathway
Reactome Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascadeR-HSA-2514859:Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways Visual phototransduction
Apoptotic execution phaseWP2776:Visual phototransduction
References
Ref 546113Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006417)
Ref 526603Bioorg Med Chem Lett. 2003 May 5;13(9):1523-6.A novel metal-chelating inhibitor of protein farnesyltransferase.

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