Drug General Information
Drug ID
D0C2DS
Former ID
DIB008737
Drug Name
KP-201 hydrocodone prodrug
Synonyms
KP-201; PF-06 program; Hydrocodone prodrug (oral, pain), KemPharm; Hydrocodone prodrug (Bio-MD, pain), PharmacoFore; Hydrocodone prodrug (Bio-MD/immediate release, pain), PharmacoFore; Hydrocodone prodrug (Bio-MD/MPAR/oral, pain), PharmacoFore; Hydrocodone prodrug (Bio-MD/MPAR/oral/immediate release, pain), PharmacoFore
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Phase 1 [549468]
Company
KemPharm Inc; PharmacoFore Inc
Structure
Download
2D MOL

3D MOL

Formula
C18H21NO3
Canonical SMILES
CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(=O)CC4
InChI
1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-12,17H,4-5,7-9H2,1-2H3/t11-,12+,17-,18-/m0/s1
InChIKey
LLPOLZWFYMWNKH-CMKMFDCUSA-N
CAS Number
CAS 125-29-1
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Agonist [551068]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 549468Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037883)
Ref 551068Clinical pipeline report, company report or official report of kempharm.

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