Drug Information

Drug General Information
Drug ID
D0C0LG
Former ID
DNC013297
Drug Name
N-(1-(1-phenylethyl)piperidin-4-yl)-2-naphthamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528639]
Structure
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2D MOL

3D MOL
Formula
C24H26N2O
Canonical SMILES
CC(C1=CC=CC=C1)N2CCC(CC2)NC(=O)C3=CC4=CC=CC=C4C=C3
InChI
1S/C24H26N2O/c1-18(19-7-3-2-4-8-19)26-15-13-23(14-16-26)25-24(27)22-12-11-20-9-5-6-10-21(20)17-22/h2-12,17-18,23H,13-16H2,1H3,(H,25,27)
InChIKey
LVIBIBUWEMTPMC-UHFFFAOYSA-N
PubChem Compound ID
44426508
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [528639]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 528639Bioorg Med Chem Lett. 2007 Mar 15;17(6):1565-9. Epub 2007 Jan 8.Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D2L, D4.2, and 5-HT2A receptors.
Ref 528639Bioorg Med Chem Lett. 2007 Mar 15;17(6):1565-9. Epub 2007 Jan 8.Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D2L, D4.2, and 5-HT2A receptors.

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