Drug Information

Drug General Information
Drug ID
D0BD3U
Former ID
DNC004300
Drug Name
SDZ-64-412
Drug Type
Small molecular drug
Indication Discovery agent Terminated [539164], [544521]
Structure
Download
2D MOL

3D MOL
Formula
C28H28N2O3
InChI
InChI=1S/C28H28N2O3/c1-31-25-16-20(17-26(32-2)27(25)33-3)9-8-19-10-12-21(13-11-19)24-18-22-6-4-5-7-23(22)28-29-14-15-30(24)28/h4-7,10-13,16-18H,8-9,14-15H2,1-3H3
InChIKey
FKRBSORUVOGNEK-UHFFFAOYSA-N
PubChem Compound ID
159547
PubChem Substance ID
14905913, 23920631, 46234771, 76749541, 85230051, 103211759, 103973600, 113442627, 127861162, 134341505, 135651034, 162972624, 234557498
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Inhibitor [533935]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 539164(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1855).
Ref 544521Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000046)
Ref 533935J Med Chem. 1993 Oct 15;36(21):3098-102.Structural modification of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinoline platelet activating factor receptor antagonists.

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