Drug Information

Drug General Information
Drug ID
D0B4TT
Former ID
DCL000399
Drug Name
GSK1004723
Drug Type
Small molecular drug
Indication Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4] Discontinued in Phase 1 [548732]
Company
GSK
Structure
Download
2D MOL

3D MOL
Formula
C39H49ClN4O2
Canonical SMILES
C1CCCN(CC1)CCCOC2=CC=C(C=C2)CCCCN3CCCC3CN4C(=O)C5=CC=CC<br />=C5C(=N4)CC6=CC=C(C=C6)Cl
InChI
1S/C39H49ClN4O2/c40-33-19-15-32(16-20-33)29-38-36-13-3-4-14-37(36)39(45)44(41-38)30-34-12-9-27-43(34)26-8-5-11-31-17-21-35(22-18-31)46-28-10-25-42-23-6-1-2-7-24-42/h3-4,13-22,34H,1-2,5-12,23-30H2/t34-/m0/s1
InChIKey
YANGEESWIGIKOP-UMSFTDKQSA-N
PubChem Compound ID
24803482
PubChem Substance ID
49749616, 57119674, 131282312, 137524674, 141449602, 163367306, 228894056, 245263398
Target and Pathway
Target(s) Histamine H3 receptor Target Info Antagonist [550963]
Histamine H1 receptor Target Info Antagonist [550963]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (i) signalling eventsR-HSA-390650:Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
References
Ref 548732Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028155)
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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