Drug Information

Drug General Information
Drug ID
D0B4SF
Former ID
DIB020048
Drug Name
impromidine
Synonyms
SK&F-92676-A3
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538738]
Structure
Download
2D MOL
Formula
C14H23N7S
InChI
InChI=1S/C14H23N7S/c1-11-13(21-10-19-11)8-22-6-5-18-14(15)17-4-2-3-12-7-16-9-20-12/h7,9-10H,2-6,8H2,1H3,(H,16,20)(H,19,21)(H3,15,17,18)
InChIKey
MURRAGMMNAYLNA-UHFFFAOYSA-N
PubChem Compound ID
41376
PubChem Substance ID
7979601, 15396446, 34707023, 47805587, 48329105, 49846698, 50064900, 50343840, 57312543, 85209115, 103173476, 103856725, 104336820, 126416144, 128650442, 134222390, 135003055, 135650388, 135934403, 137132874, 160849361, 179225827, 179293852, 198950151, 224790519, 226735130, 235140154, 241096440
Target and Pathway
Target(s) Histamine H2 receptor Target Info Agonist [527955]
Histamine H1 receptor Target Info Antagonist [527955]
Histamine H4 receptor Target Info Agonist [527589]
Histamine H3 receptor Target Info Agonist [535111]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channelshsa04080:Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathwayP04385:Histamine H1 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling eventsR-HSA-390650:Histamine receptors
G alpha (q) signalling eventsR-HSA-390650:Histamine receptors
G alpha (i) signalling eventsR-HSA-390650:Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signalingWP1825:GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP727:Monoamine Transport
References
Ref 538738(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1226).
Ref 527589Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J Pharmacol Exp Ther. 2005 Sep;314(3):1310-21. Epub 2005 Jun 9.
Ref 527955Probing ligand-specific histamine H1- and H2-receptor conformations with NG-acylated Imidazolylpropylguanidines. J Pharmacol Exp Ther. 2006 Apr;317(1):139-46. Epub 2006 Jan 4.
Ref 535111Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.