Drug Information

Drug General Information
Drug ID
D0B4IF
Former ID
DAP000630
Drug Name
Ketoconazole
Synonyms
Fungarest; Fungoral; KCZ; KTZ; Ketoconazol; Ketoderm; K 1003; R 41400; R41400; KS-1205; KW-1414; Nizoral (TN); Perkhotal (TN); R 41,400; R-41400; R41,400; Ketoconazole [USAN:INN:BAN:JAN]; Nizoral, Extina, Xolegel, Kuric, Ketoconazole; Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-piperazine; Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine; CIS-1-ACETYL-4-(4-((2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL)METHOXY)PHENYL)PIPERAZINE; (+)-Ketoconazole; (+-)-cis-1-Acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine; (+/-)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine; (+/-)-cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine; 1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone; 1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
Drug Type
Small molecular drug
Indication Fungal infections [ICD9: 110-118; ICD10:B35-B49] Approved [538296], [539659]
Therapeutic Class
Antifungal Agents
Company
Johnson & Johnson
Structure
Download
2D MOL

3D MOL
Formula
C26H28Cl2N4O4
InChI
InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3
InChIKey
XMAYWYJOQHXEEK-UHFFFAOYSA-N
CAS Number
CAS 65277-42-1
PubChem Compound ID
3823
PubChem Substance ID
456469, 5316931, 8152421, 11407121, 29222942, 46506746, 46530753, 47261387, 51021382, 57322009, 85087144, 85174349, 85787593, 93620728, 103845251, 104014719, 104304628, 117361105, 117571495, 118836543, 125355519, 125357821, 125433866, 125544749, 126685446, 126728346, 127316656, 127316657, 127316658, 127316659, 127316660, 129708236, 135650454, 137100792, 142426911, 143837446, 152057681, 162022954, 162092001, 162914824, 163315720, 164811453, 164830408, 172824381, 179116748, 223677862, 223726587, 226399613, 252825836
ChEBI ID
ChEBI:47519
SuperDrug ATC ID
D01AC08; G01AF11; J02AB02
SuperDrug CAS ID
cas=065277421
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Fungal Cytochrome P450 51 Target Info Inhibitor [537556]
References
Ref 538296FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 075273.
Ref 539659(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2568).
Ref 537556Clinical pharmacokinetics and pharmacodynamics of solifenacin. Clin Pharmacokinet. 2009;48(5):281-302. doi: 10.2165/00003088-200948050-00001.

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