Drug General Information
Drug ID	D0B2FE
Former ID	DNC010607
Drug Name	4-phenyl-6-propylpyrimidine-2-carbonitrile
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531005]
Structure		Download 2D MOL 3D MOL
Formula	C14H13N3
Canonical SMILES	CCCC1=NC(=NC(=C1)C2=CC=CC=C2)C#N
InChI	1S/C14H13N3/c1-2-6-12-9-13(17-14(10-15)16-12)11-7-4-3-5-8-11/h3-5,7-9H,2,6H2,1H3
InChIKey	IUPDRSKJKKTVKP-UHFFFAOYSA-N
PubChem Compound ID	46882093
Target and Pathway
Target(s)	Cathepsin K	Target Info	Inhibitor	[531005]
KEGG Pathway	Lysosome
	Osteoclast differentiation
	Toll-like receptor signaling pathway
	Rheumatoid arthritis
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
	RANKL Signaling Pathway
	IL2 Signaling Pathway
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
	Trafficking and processing of endosomal TLR
	MHC class II antigen presentation
WikiPathways	RANKL/RANK Signaling Pathway
	Osteoclast Signaling
References
Ref 531005	Bioorg Med Chem Lett. 2010 Aug 1;20(15):4447-50. Epub 2010 Jun 15.2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors.
Ref 531005	Bioorg Med Chem Lett. 2010 Aug 1;20(15):4447-50. Epub 2010 Jun 15.2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors.

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