Drug General Information
Drug ID	D0B1PD
Former ID	DIB006129
Drug Name	NPC-16377
Drug Type	Small molecular drug
Indication	Psychotic disorders [ICD9: 290-299; ICD10:F20-F29]		Terminated	[545059]
Company	Scios Inc
Structure		Download 2D MOL 3D MOL
Formula	C27H34ClNO4
Canonical SMILES	c1(c(oc2c(c1=O)cc(cc2)OCCCCCCN1CCC(CC1)O)c1ccccc1)C.Cl
CAS Number	CAS 139652-86-1
PubChem Compound ID	9890958
Target and Pathway
Target(s)	Sigma(1)-type opioid receptor	Target Info	Modulator	[526642], [532713], [533992]
WikiPathways	miR-targeted genes in squamous cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
References
Ref 545059	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001997)
Ref 526642	Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6.
Ref 532713	Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.
Ref 533992	Effects of the selective sigma receptor ligand, 6-[6-(4-hydroxypiperidinyl)hexyloxy]-3-methylflavone (NPC 16377), on behavioral and toxic effects of cocaine. J Pharmacol Exp Ther. 1993 Aug;266(2):473-82.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.