Drug Information

Drug General Information
Drug ID
D0AT5N
Former ID
DIB018618
Drug Name
4-arylphthalazin-1(2H)-3,4-Di-F
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531725]
Structure
Download
2D MOL
Formula
C30H30F2N4O2
InChI
InChI=1S/C30H30F2N4O2/c1-20(37)33-24-7-4-6-22(18-24)21-12-16-35(17-13-21)14-5-15-36-30(38)26-9-3-2-8-25(26)29(34-36)23-10-11-27(31)28(32)19-23/h2-4,6-11,18-19,21H,5,12-17H2,1H3,(H,33,37)
InChIKey
YVVMAGRTTSOPEO-UHFFFAOYSA-N
PubChem Compound ID
56835134
PubChem Substance ID
134961838, 136928333, 136964920, 223366086
Target and Pathway
Target(s) Melanin-concentrating hormone receptor 1 Target Info Antagonist [531725]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 5317254-arylphthalazin-1(2H)-one derivatives as potent antagonists of the melanin concentrating hormone receptor 1 (MCH-R1). Bioorg Med Chem Lett. 2012 Jan 1;22(1):427-30.
Ref 5317254-arylphthalazin-1(2H)-one derivatives as potent antagonists of the melanin concentrating hormone receptor 1 (MCH-R1). Bioorg Med Chem Lett. 2012 Jan 1;22(1):427-30.

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