Drug Information
Drug General Information | |||||
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Drug ID |
D0AP4O
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Former ID |
DPR000123
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Drug Name |
Gem 92
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Drug Type |
Antisense drug
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Indication | HIV-1 infection [ICD9: 001-139, 042; ICD10:B20-B24] | Discontinued in Phase 1 | [546454] | ||
Therapeutic Class |
Antisense
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Company |
Idera Pharmaceuticals
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Target and Pathway | |||||
Target(s) | HIV GAG protein | Target Info | Modulator | ||
Reactome | Uncoating of the HIV Virion | ||||
Budding and maturation of HIV virion | |||||
Integration of provirus | |||||
Early Phase of HIV Life Cycle | |||||
Minus-strand DNA synthesis | |||||
Plus-strand DNA synthesis | |||||
2-LTR circle formation | |||||
Binding and entry of HIV virion | |||||
Membrane binding and targetting of GAG proteins | |||||
Assembly Of The HIV Virion | |||||
Integration of viral DNA into host genomic DNA | |||||
Autointegration results in viral DNA circles | |||||
APOBEC3G mediated resistance to HIV-1 infection | |||||
Vpr-mediated nuclear import of PICs | |||||
WikiPathways | Host Interactions of HIV factors | ||||
HIV Life Cycle | |||||
References |
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