Drug General Information
Drug ID
D0AP4O
Former ID
DPR000123
Drug Name
Gem 92
Drug Type
Antisense drug
Indication HIV-1 infection [ICD9: 001-139, 042; ICD10:B20-B24] Discontinued in Phase 1 [546454]
Therapeutic Class
Antisense
Company
Idera Pharmaceuticals
Target and Pathway
Target(s) HIV GAG protein Target Info Modulator
Reactome Uncoating of the HIV Virion
Budding and maturation of HIV virion
Integration of provirus
Early Phase of HIV Life Cycle
Minus-strand DNA synthesis
Plus-strand DNA synthesis
2-LTR circle formation
Binding and entry of HIV virion
Membrane binding and targetting of GAG proteins
Assembly Of The HIV Virion
Integration of viral DNA into host genomic DNA
Autointegration results in viral DNA circles
APOBEC3G mediated resistance to HIV-1 infection
Vpr-mediated nuclear import of PICs
WikiPathways Host Interactions of HIV factors
HIV Life Cycle
References
Ref 546454Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008217)

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.