Drug General Information
Drug ID	D0AL3O
Former ID	DIB009483
Drug Name	VX-366
Synonyms	Isobutyramide; Isobutyramide, Vertex
Indication	Hematopoietic [ICD10:D50-D89]		Discontinued in Phase 2	[546039]
Company	Vertex Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(=O)(N)C(C)C
CAS Number	CAS 563-83-7
Target and Pathway
Target(s)	Hemoglobin	Target Info	Inhibitor	[525637]
KEGG Pathway	African trypanosomiasis
	Malaria
Reactome	Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Scavenging of heme from plasma
WikiPathways	Binding and Uptake of Ligands by Scavenger Receptors
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
	Factors involved in megakaryocyte development and platelet production
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
References
Ref 546039	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006007)
Ref 525637	A combination of hydroxyurea and isobutyramide to induce fetal hemoglobin in transgenic mice is more hematotoxic than the individual agents. Blood Cells Mol Dis. 1999 Jun-Aug;25(3-4):255-69.

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