Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0AE3X
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| Former ID |
DIB014822
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| Drug Name |
Brimonidine
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| Synonyms |
Brimonidine (bioerodible, extended release)
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| Drug Type |
Small molecular drug
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| Indication | Ocular hypertension [ICD9: 365.04; ICD10:H40.0] | Approved | [1], [2] | ||
| Company |
PSivida Corp
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| Structure |
|
Download2D MOL |
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| Formula |
C11H10BrN5
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| InChI |
InChI=1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)
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| InChIKey |
XYLJNLCSTIOKRM-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID |
10088, 456619, 840957, 842087, 855898, 5580998, 7978815, 8151624, 11111939, 11113354, 14751364, 14922559, 17405770, 24277812, 26751556, 29215016, 29221599, 46507305, 47216864, 47515407, 48259343, 50043889, 50100366, 50104157, 50104158, 50500871, 51091862, 53778322, 53788848, 56422176, 56464105, 57321312, 62132787, 85209347, 85231282, 90340645, 92303234, 92717780, 93166807, 103144193, 103221477, 104170136, 104171261, 104300578, 117387171, 117389891, 118048633, 118874971, 121361838, 121362629
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| Target and Pathway | |||||
| Target(s) | Alpha-2C adrenergic receptor | Target Info | Modulator | [1] | |
| KEGG Pathway | cGMP-PKG signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| PANTHER Pathway | Alpha adrenergic receptor signaling pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Reactome | Adrenoceptors | ||||
| Adrenaline signalling through Alpha-2 adrenergic receptor | |||||
| Adrenaline,noradrenaline inhibits insulin secretion | |||||
| G alpha (i) signalling events | |||||
| G alpha (z) signalling events | |||||
| Surfactant metabolism | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Platelet Aggregation (Plug Formation) | |||||
| Integration of energy metabolism | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 520). | ||||
| REF 2 | ClinicalTrials.gov (NCT00675207) Comparison of Brimonidine Purite, Dorzolamide, and Brinzolamide as Adjunctive Therapy to Prostaglandin Analogs. U.S. National Institutes of Health. | ||||
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