Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0AA2D
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| Former ID |
DAP000877
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| Drug Name |
Bifonazole
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| Synonyms |
Amycor; Azolmen; Bifokey; Bifomyk; Bifon; Bifonazol; Bifonazolum; Moldina; Mycospor; Trifonazole; Bayer brand of bifonazole; Bioglan brand of bifonazole; Canesten Extra Bifonazol; Canesten brand of bifonazole; Dermapharm brand of bifonazole; Inkeysa brand of bifonazole; Juventus brand of bifonazole; Merck Lipha Sante brand of bifonazole; Bay H-4502; Bifonazol [INN-Spanish]; Bifonazolum [INN-Latin]; Canespor (TN); Mycospor (TN); Bay-h-4502; Bifonazole (JP15/USAN/INN); Bifonazole [USAN:BAN:INN:JAN]; (+-)-1-([1,1'-Biphenyl]-4-ylphenylmethyl)-1H-imidazole; (+-)-1-(p,alpha-Diphenylbenzyl)imidazole; 1-((4-Biphenylyl)phenylmethyl)-1H-imidazole; 1-(alpha-(4-Biphenylyl)benzyl)imidazole; 1-(p,alpha-Diphenylbenzyl)imidazole; 1-[4,alpha-Diphenylbenzyl]-imidazole; 1-[biphenyl-4-yl(phenyl)methyl]-1H-imidazole; 1-[phenyl-(4-phenylphenyl)methyl]imidazole
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| Drug Type |
Small molecular drug
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| Indication | Fungal infections [ICD9: 110-118; ICD10:B35-B49] | Approved | [550663] | ||
| Therapeutic Class |
Antifungal Agents
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| Company |
Bayer Pharmaceuticals Corporation
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| Structure |
|
Download2D MOL |
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| Formula |
C22H18N2
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| Canonical SMILES |
C1=CC=C(C=C1)C2=CC=C(C=C2)C(C3=CC=CC=C3)N4C=CN=C4
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| InChI |
1S/C22H18N2/c1-3-7-18(8-4-1)19-11-13-21(14-12-19)22(24-16-15-23-17-24)20-9-5-2-6-10-20/h1-17,22H
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| InChIKey |
OCAPBUJLXMYKEJ-UHFFFAOYSA-N
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| CAS Number |
CAS 60628-96-8
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| PubChem Compound ID | |||||
| PubChem Substance ID |
603868, 855867, 4422038, 7848838, 8151596, 11373018, 11483865, 11487851, 11491785, 12013311, 14874247, 26612889, 26680150, 26719682, 26747221, 26747222, 29221545, 46386787, 46507284, 47359445, 49833729, 49979108, 50105275, 53790254, 56422098, 57321292, 77059268, 81092785, 85084179, 85171922, 85788008, 92124602, 92307859, 92308334, 92309209, 92714230, 99351129, 103179440, 104020311, 104171382, 104300416, 117814570, 124637818, 124658982, 124766210, 124800208, 124883565, 124883566, 124883567, 125354196
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| SuperDrug ATC ID |
D01AC10
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| SuperDrug CAS ID |
cas=060628968
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| Target and Pathway | |||||
| Target(s) | Fungal Cytochrome P450 51 | Target Info | Inhibitor | [536289], [537801], [537803] | |
| References | |||||
| Ref 536289 | Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme. Arch Biochem Biophys. 2006 Nov 1;455(1):61-7. Epub 2006 Sep 25. | ||||
| Ref 537801 | Bifonazole and clotrimazole. Their mode of action and the possible reason for the fungicidal behaviour of bifonazole. Arzneimittelforschung. 1984;34(2):139-46. | ||||
| Ref 537803 | Bifonazole, a biochemist's view. Dermatologica. 1984;169 Suppl 1:3-9. | ||||
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