Drug General Information
Drug ID	D0A7KI
Former ID	DIB007980
Drug Name	Abaperidone
Synonyms	FI-8602
Drug Type	Small molecular drug
Indication	Schizophrenia [ICD9: 295; ICD10:F20]		Phase 1	[551815]
Company	Ferrer Internacional SA
Structure		Download 2D MOL 3D MOL
Formula	C25H25FN2O5
Canonical SMILES	n1c(c2c(o1)cc(cc2)F)C1CCN(CC1)CCCOc1cc2c(c(=O)c(co2)CO)<br />cc1
CAS Number	CAS 183849-43-6
PubChem Compound ID	3037308
Target and Pathway
Target(s)	5-hydroxytryptamine 2A receptor	Target Info	Modulator	[553290]
	D(2) dopamine receptor	Target Info	Modulator	[553290]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channelshsa04015:Rap1 signaling pathway
	cAMP signaling pathway
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholism
PANTHER Pathway	5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Serotonin receptors
	G alpha (q) signalling eventsR-HSA-390651:Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Serotonin Receptor 2 and STAT3 Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
	Genes and (Common) Pathways Underlying Drug Addiction
	Nicotine Activity on Dopaminergic Neurons
References
Ref 551815	Small Molecule Therapeutics for Schizophrenia, Sylvain Celanire. Page(30).
Ref 553290	7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602). J Med Chem. 1998 Dec 31;41(27):5402-9.

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