Drug General Information
Drug ID	D0A7JH
Former ID	DIB004285
Drug Name	WY-50295-tromethamine
Synonyms	WY-50295T; Wy-49232
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Phase 2	[525487]
Company	Wyeth-Ayerst Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Formula	C27H30N2O6
Canonical SMILES	n1c2c(ccc1COc1cc3c(cc([C@@H](C(=O)O)C)cc3)cc1)cccc2
CAS Number	CAS 123016-21-7
PubChem Compound ID	44149608
Target and Pathway
Target(s)	Arachidonate 5-lipoxygenase	Target Info	Inhibitor	[525487]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Resolvin D biosynthesis
	Leukotriene biosynthesis
	Lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	Serotonergic synapse
	Ovarian steroidogenesis
	Toxoplasmosis
NetPath Pathway	IL4 Signaling Pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Vitamin D Receptor Pathway
	Arachidonic acid metabolism
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 525487	WY-50295 tromethamine: a 5-lipoxygenase inhibitor without activity in human whole blood. Prostaglandins Leukot Essent Fatty Acids. 1999 Jan;60(1):31-41.
Ref 525487	WY-50295 tromethamine: a 5-lipoxygenase inhibitor without activity in human whole blood. Prostaglandins Leukot Essent Fatty Acids. 1999 Jan;60(1):31-41.

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