Drug General Information
Drug ID	D0A5RD
Former ID	DCL000947
Drug Name	Radafaxine
Synonyms	Hydroxybupropion
Drug Type	Small molecular drug
Indication	Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32]		Discontinued in Phase 2	[536295]
Company	GlaxoSmithKline
Structure		Download 2D MOL 3D MOL
Formula	C13H19ClNO2+
Canonical SMILES	CC(C(=O)C1=CC(=CC=C1)Cl)[NH2+]C(C)(C)CO
InChI	1S/C13H18ClNO2/c1-9(15-13(2,3)8-16)12(17)10-5-4-6-11(14)7-10/h4-7,9,15-16H,8H2,1-3H3/p+1
InChIKey	AKOAEVOSDHIVFX-UHFFFAOYSA-O
CAS Number	CAS 106083-71-0
PubChem Compound ID	25202442
PubChem Substance ID	585033, 135362986, 172125904
Target and Pathway
Target(s)	Dopamine reuptake	Target Info	Inhibitor	[536122], [536295]
	Sodium-dependent noradrenaline transporter	Target Info	Inhibitor	[536122], [536295]
PANTHER Pathway	Adrenaline and noradrenaline biosynthesis
Reactome	Na+/Cl- dependent neurotransmitter transporters
WikiPathways	Monoamine Transport
	NRF2 pathway
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 536295	Emerging drugs for bipolar disorder. Expert Opin Emerg Drugs. 2006 Nov;11(4):621-34.
Ref 536122	Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
Ref 536295	Emerging drugs for bipolar disorder. Expert Opin Emerg Drugs. 2006 Nov;11(4):621-34.

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