Drug Information

Drug General Information
Drug ID
D0A5MI
Former ID
DIB016280
Drug Name
LANIQUIDAR
Synonyms
R-101933; Laniquidar < Prop INN >; 11-[1-[2-[4-(2-Quinolylmethoxy)phenyl]ethyl]piperidin-4-ylidene]-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine-3-carboxylic acid methyl ester
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Discontinued in Phase 2 [521501]
Structure
Download
2D MOL

3D MOL
Formula
C37H36N4O3
Canonical SMILES
COC(=O)c1cnc2C(=C3CCN(CCc4ccc(OCc5ccc6ccccc6n5)cc4)CC3)<br />c7ccccc7CCn12
InChI
1S/C37H36N4O3/c1-43-37(42)34-24-38-36-35(32-8-4-2-6-27(32)19-23-41(34)36)29-17-21-40(22-18-29)20-16-26-10-14-31(15-11-26)44-25-30-13-12-28-7-3-5-9-33(28)39-30/h2-15,24H,16-23,25H2,1H3
InChIKey
TULGGJGJQXESOO-UHFFFAOYSA-N
PubChem Compound ID
6450806
Target and Pathway
Target(s) Multidrug resistance protein 3 Target Info Modulator [530287]
KEGG Pathway ABC transporters
Bile secretion
Reactome PPARA activates gene expression
ABC-family proteins mediated transport
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Farnesoid X Receptor Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
References
Ref 521501ClinicalTrials.gov (NCT00028873) R101933 Combined With Chemotherapy in Treating Patients With Metastatic Breast Cancer That Has Not Responded to Previous Chemotherapy. U.S. National Institutes of Health.
Ref 530287Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in rats. Nucl Med Biol. 2009 Aug;36(6):643-9.

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