Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0A4EA
|
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| Former ID |
DNC010898
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| Drug Name |
OLEIC ACID
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C18H34O2
|
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| InChI |
InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-
|
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| InChIKey |
ZQPPMHVWECSIRJ-KTKRTIGZSA-N
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| CAS Number |
CAS 112-80-1
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
3978, 75221, 584561, 607054, 819801, 820852, 823248, 841649, 3140740, 4265936, 7849374, 7889573, 7889575, 8136926, 8144974, 10299740, 10504339, 11528277, 11532519, 14750979, 17388831, 24278605, 24856748, 24862437, 24886786, 24897936, 24897941, 24897944, 24897946, 24901337, 24901338, 26708080, 26732603, 26752911, 26759285, 29204451, 36888286, 46391972, 46392022, 46392136, 46393429, 48185141, 48417325, 48423867, 48425443, 49854224, 53789356, 56311729, 56314553, 56365484
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| Target and Pathway | |||||
| Target(s) | Fatty acid-binding protein, adipocyte | Target Info | Inhibitor | [2] | |
| Fatty acid-binding protein, liver | Target Info | Inhibitor | [3] | ||
| KEGG Pathway | PPAR signaling pathwayhsa03320:PPAR signaling pathway | ||||
| Fat digestion and absorption | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| Pathway Interaction Database | AP-1 transcription factor network | ||||
| Reactome | Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis | ||||
| Transcriptional regulation of white adipocyte differentiationR-HSA-163560:Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis | |||||
| PPARA activates gene expression | |||||
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||||
| WikiPathways | Lipid digestion, mobilization, and transport | ||||
| Transcriptional Regulation of White Adipocyte DifferentiationWP2882:Nuclear Receptors Meta-Pathway | |||||
| PPAR Alpha Pathway | |||||
| Selenium Metabolism and Selenoproteins | |||||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1054). | ||||
| REF 2 | Bioorg Med Chem Lett. 2010 Jun 15;20(12):3675-9. Epub 2010 Apr 24.Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. | ||||
| REF 3 | J Med Chem. 2008 Jul 10;51(13):3755-64. Epub 2008 Jun 6.Characterization of the drug binding specificity of rat liver fatty acid binding protein. | ||||
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